The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migration.

ABSTRACT:

Background

Bone morphogenetic proteins (BMPs) have been shown to participate in the patterning and specification of several tissues and organs during development and to regulate cell growth, differentiation and migration in different cell types. BMP-mediated cell migration requires activation of the small GTPase Cdc42 and LIMK1 activities. In our earlier report we showed that activation of LIMK1 also requires the activation of PAKs through Cdc42 and PI3K. However, the requirement of additional signaling is not clearly known.

Methodology/principal findings

Activation of p38 MAPK has been shown to be relevant for a number of BMP-2's physiological effects. We report here that BMP-2 regulation of cell migration and actin cytoskeleton remodelling are dependent on p38 activity. BM

SUBMITTER: Gamell C 

PROVIDER: S-EPMC3030584 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature