Association of coagulation-related and inflammation-related genes and factor VIIc levels with stroke: the Cardiovascular Health Study.

ABSTRACT:

Background

Thrombosis and inflammation are critical in stroke etiology, but associations of coagulation and inflammation gene variants with stroke, and particularly factor VII levels, are inconclusive.

Objectives

To test the associations between 736 single-nucleotide polymorphisms (SNPs) between tagging haplotype patterns of 130 coagulation and inflammation genes, and stroke events, in the 5888 participants aged ≥ 65 years of the observational Cardiovascular Health Study cohort.

Patients/methods

With 16 years of follow-up, age-adjusted and sex-adjusted Cox models were used to estimate associations of SNPs and FVIIc levels with future stroke.

Results

Eight hundred and fifteen strokes occurred in 5255 genotyped participants without baseline stroke (748 ischemic s

SUBMITTER: Zakai NA 

PROVIDER: S-EPMC3030667 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature