Variable effect of P2Y12 inhibition on platelet thrombus volume in flowing blood.

ABSTRACT:

Background and objectives

Patients treated with percutaneous coronary intervention receive aspirin and P2Y12 ADP receptor inhibitors to reduce thrombotic complications. The choice of methodology for monitoring the effects of treatment and assessing its efficacy is still a topic of debate. We evaluated how decreased P2Y12 function influences platelet aggregate (thrombus) size measured ex vivo.

Methods and results

We used confocal videomicroscopy to measure in real time the volume of platelet thrombi forming upon blood perfusion over fibrillar collagen type I at a wall shear rate of 1500 s(-1). The average volume was significantly smaller in 31 patients receiving aspirin and clopidogrel (19) or ticlopidine (12) than in 21 controls, but individual values were above the lower li

SUBMITTER: Mendolicchio GL 

PROVIDER: S-EPMC3030676 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature