Improving evolutionary models of protein interaction networks.

ABSTRACT:

Motivation

Theoretical models of biological networks are valuable tools in evolutionary inference. Theoretical models based on gene duplication and divergence provide biologically plausible evolutionary mechanics. Similarities found between empirical networks and their theoretically generated counterpart are considered evidence of the role modeled mechanics play in biological evolution. However, the method by which these models are parameterized can lead to questions about the validity of the inferences. Selecting parameter values in order to produce a particular topological value obfuscates the possibility that the model may produce a similar topology for a large range of parameter values. Alternately, a model may produce a large range of topologies, allowing (incorrect) parameter

SUBMITTER: Gibson TA 

PROVIDER: S-EPMC3031028 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature