Toward the estimation of the absolute quality of individual protein structure models.

ABSTRACT:

Motivation

Quality assessment of protein structures is an important part of experimental structure validation and plays a crucial role in protein structure prediction, where the predicted models may contain substantial errors. Most current scoring functions are primarily designed to rank alternative models of the same sequence supporting model selection, whereas the prediction of the absolute quality of an individual protein model has received little attention in the field. However, reliable absolute quality estimates are crucial to assess the suitability of a model for specific biomedical applications.

Results

In this work, we present a new absolute measure for the quality of protein models, which provides an estimate of the 'degree of nativeness' of the structural features

SUBMITTER: Benkert P 

PROVIDER: S-EPMC3031035 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature