Ontology highlight
ABSTRACT:
SUBMITTER: Quintana E
PROVIDER: S-EPMC3031091 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Cancer cell 20101101 5
We investigated whether melanoma is hierarchically organized into phenotypically distinct subpopulations of tumorigenic and nontumorigenic cells or whether most melanoma cells retain tumorigenic capacity, irrespective of their phenotype. We found 28% of single melanoma cells obtained directly from patients formed tumors in NOD/SCID IL2Rγ(null) mice. All stage II, III, and IV melanomas obtained directly from patients had common tumorigenic cells. All tumorigenic cells appeared to have unlimited t ...[more]