New antibody to stop tumor angiogenesis and lymphatic spread by blocking receptor partnering.

ABSTRACT: Tvorogov et al. (2010) describe in this issue of Cancer Cell an antibody that inhibits homodimerization of vascular endothelial growth factor receptor-3 (VEGFR-3) and its heterodimerization with VEGFR-2, but not ligand binding. The work provides mechanistic insights into receptor dimerization and an approach to suppress both angiogenesis and lymphangiogenesis.

SUBMITTER: McDonald DM 

PROVIDER: S-EPMC3031147 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature