Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation.

ABSTRACT: Regulators of G-protein signaling (RGS) proteins are scaffolds that control diverse signaling pathways by modulating signalosome formation and by accelerating the GTPase activity of heterotrimeric G proteins. Although expression of many RGS proteins is relatively low in quiescent cells, transcriptional and post-translational responses to environmental cues regulate both their abundance and activity. We found previously that RGS13, one of the smallest RGS proteins in the family, inhibited cyclic AMP-dependent protein kinase (PKA)-induced gene expression through interactions with the transcription factor cAMP-response element-binding (CREB) protein. Here, we show that PKA activation also leads to increased steady-state RGS13 expression through RGS13 phosphorylation, which inhibits RGS13 prot

SUBMITTER: Xie Z 

PROVIDER: S-EPMC3031343 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature