Ontology highlight
ABSTRACT:
SUBMITTER: Nichol D
PROVIDER: S-EPMC3031397 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Nichol Donna D Shawber Carrie C Fitch Michael J MJ Bambino Kathryn K Sharma Anshula A Kitajewski Jan J Stuhlmann Heidi H
Blood 20101014 26
Epidermal growth factor-like domain 7 (Egfl7) is important for regulating tubulogenesis in zebrafish, but its role in mammals remains unresolved. We show here that endothelial overexpression of Egfl7 in transgenic mice leads to partial lethality, hemorrhaging, and altered cardiac morphogenesis. These defects are accompanied by abnormal vascular patterning and remodeling in both the embryonic and postnatal vasculature. Egfl7 overexpression in the neonatal retina results in a hyperangiogenic respo ...[more]