Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer.

ABSTRACT: Duplication of chromosomal arm 20q occurs in prostate, cervical, colon, gastric, bladder, melanoma, pancreas and breast cancer, suggesting that 20q amplification may play a causal role in tumorigenesis. According to an alternative view, chromosomal imbalance is mainly a common side effect of cancer progression. To test whether a specific genomic aberration might serve as a cancer initiating event, we established an in vitro system that models the evolutionary process of early stages of prostate tumor formation; normal prostate cells were immortalized by the over-expression of human telomerase catalytic subunit hTERT, and cultured for 650 days till several transformation hallmarks were observed. Gene expression patterns were measured and chromosomal aberrations were monitored by spectral ka

SUBMITTER: Tabach Y 

PROVIDER: S-EPMC3031497 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature