Regulation of human neurotropic JC virus replication by alternative splicing factor SF2/ASF in glial cells.

ABSTRACT:

Background

The human neurotropic virus, JC virus (JCV), is the etiologic agent of the fatal demyelinating disease of the central nervous system, Progressive Multifocal Leukoencephalopathy (PML) that is seen primarily in immunodeficient individuals. Productive infection of JCV occurs only in glial cells, and this restriction is, to a great extent, due to the activation of the viral promoter that has cell type-specific characteristics. Earlier studies led to the hypothesis that glial-specific activation of the JCV promoter is mediated through positive and negative transcription factors that control reactivation of the JCV genome under normal physiological conditions and suppress its activation in non-glial cells.

Methodology/principal findings

Using a variety of virological an

SUBMITTER: Sariyer IK 

PROVIDER: S-EPMC3031499 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature