CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes.

ABSTRACT:

Background

CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.

Methodology/principal findings

In addition to these previously described roles, our study shows that CDK11(p58) inhibition induces a failure in the centriole duplication process in different human cell lines. We propose that this effect is mediated by the defective centrosomal recruitment of proteins at the onset of mitosis. Indeed, Plk4 protein kinase and the centrosomal protein Cep192, which are key components of the centriole duplication machinery, showed reduced levels at centrosomes of mitotic CDK11-depleted cells. CDK11(p58), which accumulates only in the vicinity of mitotic centrosomes, d

SUBMITTER: Franck N 

PROVIDER: S-EPMC3031510 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature