Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping.

ABSTRACT: Connectivity mapping is a recently developed technique for discovering the underlying connections between different biological states based on gene-expression similarities. The sscMap method has been shown to provide enhanced sensitivity in mapping meaningful connections leading to testable biological hypotheses and in identifying drug candidates with particular pharmacological and/or toxicological properties. Challenges remain, however, as to how to prioritise the large number of discovered connections in an unbiased manner such that the success rate of any following-up investigation can be maximised. We introduce a new concept, gene-signature perturbation, which aims to test whether an identified connection is stable enough against systematic minor changes (perturbation) to the gene-sign

SUBMITTER: McArt DG 

PROVIDER: S-EPMC3031567 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature