Rescue of lethal hepatic failure by hepatized lymph nodes in mice.

ABSTRACT:

Background & aims

Hepatocyte transplantation is a potential therapeutic approach for liver disease. However, most patients with chronic hepatic damage have cirrhosis and fibrosis, which limit the potential for cell-based therapy of the liver. The development of an ectopic liver as an additional site of hepatic function represents a new approach for patients with end-stage liver disease. We investigated the development and function of liver tissue in lymph nodes in mice with liver failure.

Methods

Hepatocytes were isolated from 8- to 12-week-old mice and transplanted by intraperitoneal injection into 8- to 12-week-old fumarylacetoacetate hydrolase mice (Fah(-/-)), a model of the human liver disease tyrosinemia type I. Survival was monitored and the locations and functions of

SUBMITTER: Hoppo T 

PROVIDER: S-EPMC3031768 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature