Replication study of SNP associations for colorectal cancer in Hong Kong Chinese.

ABSTRACT:

Background

Recent genome-wide association studies of colorectal cancer (CRC) have identified common single-nucleotide polymorphisms (SNPs) mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC.

Methods

An association study was performed on 892 CRC cases and 890 controls recruited from the Hong Kong Chinese population, genotyping 32 SNPs, which were either associated with CRC in previous studies or are in close proximity to previously reported risk SNPs.

Results

Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs10795668 on 10p14, rs477958

SUBMITTER: Ho JW 

PROVIDER: S-EPMC3031883 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature