Whole-heart modeling: applications to cardiac electrophysiology and electromechanics.

ABSTRACT: Recent developments in cardiac simulation have rendered the heart the most highly integrated example of a virtual organ. We are on the brink of a revolution in cardiac research, one in which computational modeling of proteins, cells, tissues, and the organ permit linking genomic and proteomic information to the integrated organ behavior, in the quest for a quantitative understanding of the functioning of the heart in health and disease. The goal of this review is to assess the existing state-of-the-art in whole-heart modeling and the plethora of its applications in cardiac research. General whole-heart modeling approaches are presented, and the applications of whole-heart models in cardiac electrophysiology and electromechanics research are reviewed. The article showcases the contributions

SUBMITTER: Trayanova NA 

PROVIDER: S-EPMC3031963 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature