Transcriptional profiling of hypothalamus during development of adiposity in genetically selected fat and lean chickens.

ABSTRACT: The hypothalamus integrates peripheral signals to regulate food intake, energy metabolism, and ultimately growth rate and body composition in vertebrates. Deviations in hypothalamic regulatory controls can lead to accumulation of excess body fat. Many regulatory genes involved in this process remain unidentified, and comparative studies may be helpful to unravel evolutionarily conserved mechanisms controlling body weight and food intake. In the present study, divergently selected fat (FL) and lean (LL) lines of chickens were used to characterize differences in hypothalamic gene expression in these unique genetic lines that develop differences in adiposity without differences in food intake or body weight. Hypothalamic transcriptional profiles were defined with cDNA microarrays before and d

SUBMITTER: Byerly MS 

PROVIDER: S-EPMC3032285 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature