Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediate-grade primary breast cancer.

ABSTRACT: The histological manifestation of growth-regulating and differentiation-inducing signals in cancer cells is considered as a key component for clinical outcome prediction and commonly defined as tumor differentiation grade. However, the molecular and functional framework underlying this clinical parameter remains poorly understood. Our correlative data display a significant association (P>0.001) between mitochondrial uncoupling protein 2 (UCP2) and tumor grade in primary breast cancer (n=234). Through mechanistic analyses, we show a synergistic link between UCP2 and established cellular pathways in conferring grade-associated functional phenotypes. Here, the application of well to moderately differentiated primary tumor cell lines has enabled direct observation of SMAD recruitment to the UC

SUBMITTER: Sayeed A 

PROVIDER: S-EPMC3032562 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature