Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer.

ABSTRACT:

Background

Expression quantitative trait loci (eQTL) studies have helped identify the genetic determinants of gene expression. Understanding the potential interacting mechanisms underlying such findings, however, is challenging.

Methods

We describe a method to identify the trans-acting drivers of multiple gene co-expression, which reflects the action of regulatory molecules. This method-termed co-regulatory expression quantitative trait locus (creQTL) mapping-allows for evaluation of a more focused set of phenotypes within a clear biological context than conventional eQTL mapping.

Results

Applying this method to a study of endometrial cancer revealed regulatory mechanisms supported by the literature: a creQTL between a locus upstream of STARD13/DLC2 and a group of sev

SUBMITTER: Kompass KS 

PROVIDER: S-EPMC3032645 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature