Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent.

ABSTRACT:

Background

Despite an ever-improving understanding of the molecular biology of cancer, the treatment of most cancers has not changed dramatically in the past three decades and drugs that do not discriminate between tumor cells and normal tissues remain the mainstays of anticancer therapy. Since Hsp90 is typically involved in cell proliferation and survival, this is thought to play a key role in cancer, and Hsp90 has attracted considerable interest in recent years as a potential therapeutic target.

Methods

We focused on the interaction of Hsp90 with its cofactor protein p60/Hop, and engineered a cell-permeable peptidomimetic, termed "hybrid Antp-TPR peptide", modeled on the binding interface between the molecular chaperone Hsp90 and the TPR2A domain of Hop.

Results

It

SUBMITTER: Horibe T 

PROVIDER: S-EPMC3032679 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature