Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

ABSTRACT:

Background

The ubiquitin(Ub)-proteasome pathway is implicated in the regulation of a variety of cellular functions and plays a major role in stress response in eukaryotic cells, by targeting misfolded and damaged proteins for degradation. In addition, in the presence of DNA damage, the Ub-proteasome system regulates proteins involved in sensing, repairing, and/or tolerating the damage. Antitumor agents such as cisplatin can activate the pathway, but the role of specific pathway components in cell sensitivity/response to the drug is not known. Since platinum compounds represent clinically relevant antitumor agents and a major limitation to their use is the development of drug resistance, there is an urgent need for identifying targets for improving their efficacy.

Results

In

SUBMITTER: Gatti L 

PROVIDER: S-EPMC3032702 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature