Brain perihematoma genomic profile following spontaneous human intracerebral hemorrhage.

ABSTRACT:

Background

Spontaneous intracerebral hemorrhage (ICH) represents about 15% of all strokes and is associated with high mortality rates. Our aim was to identify the gene expression changes and biological pathways altered in the brain following ICH.

Methodology/principal findings

Twelve brain samples were obtained from four deceased patients who suffered an ICH including perihematomal tissue (PH) and the corresponding contralateral white (CW) and grey (CG) matter. Affymetrix GeneChip platform for analysis of over 47,000 transcripts was conducted. Microarray Analysis Suite 5.0 was used to process array images and the Ingenuity Pathway Analysis System was used to analyze biological mechanisms and functions of the genes. We identified 468 genes in the PH areas displaying a differe

SUBMITTER: Rosell A 

PROVIDER: S-EPMC3032742 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature