Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis.

ABSTRACT:

Background

Results from genetic epidemiological studies suggest that raised serum homocysteine is a cause of ischaemic heart disease, but the results of randomised trials suggest otherwise. We aimed to update meta-analyses on each type of study using the latest published data and test a hypothesis based on antiplatelet therapy use in the trials to explain the discrepancy.

Methods and findings

Meta-analyses of ischaemic heart disease using (i) 75 studies in which the prevalence of a mutation (CT) in the MTHFR gene (which increases homocysteine) was determined in cases (22,068) and controls (23,618), and (ii) 14 randomised trials (39,597 participants) of homocysteine lowering and ischaemic heart disease events. The summary estimates from the two analyses were compared. Meta-an

SUBMITTER: Wald DS 

PROVIDER: S-EPMC3032783 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature