Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice.

ABSTRACT:

Background

Although increased levels of plasminogen activators have been found in psoriatic lesions, the role of plasmin converted from plasminogen by plasminogen activators in pathogenesis of psoriasis has not been investigated.

Methodology/principal findings

Here we examined the contribution of plasmin to amplification of inflammation in patients with psoriasis. We found that plasminogen was diminished, but that the amount and activity of its converted product plasmin were markedly increased in psoriasis. Moreover, annexin II, a receptor for plasmin was dramatically increased in both dermis and epidermis in psoriasis. Plasmin at sites of inflammation was pro-inflammatory, eliciting production of inflammatory factors, including CC chemokine ligand 20 (CCL20) and interleukin

SUBMITTER: Li Q 

PROVIDER: S-EPMC3032787 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature