Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review.

ABSTRACT:

Background

Observational epidemiological studies of dietary antioxidant intake, serum antioxidant concentration and lung outcomes suggest that lower levels of antioxidant defences are associated with decreased lung function. Another approach to understanding the role of oxidant/antioxidant imbalance in the risk of chronic obstructive pulmonary disease (COPD) is to investigate the role of genetic variation in antioxidant enzymes, and indeed family based studies suggest a heritable component to lung disease. Many studies of the genes encoding antioxidant enzymes have considered COPD or COPD related outcomes, and a systematic review is needed to summarise the evidence to date, and to provide insights for further research.

Methods

Genetic association studies of antioxidant enzym

SUBMITTER: Bentley AR 

PROVIDER: S-EPMC3032799 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature