Trigger-specific risk factors and response to therapy in long QT syndrome type 2.

ABSTRACT:

Background

Cardiac events in patients with long QT syndrome type 2 (LQT2) are predominately associated with sudden arousal. However, exercise-induced events also occur in this population.

Objective

The purpose of this study was to test the hypothesis that risk factors show a trigger-specific association with cardiac events in LQT2 patients.

Methods

The study population consisted of 634 genetically confirmed LQT2 patients from the U.S. portion of the International LQTS Registry. Multivariate Cox proportional hazards regression analysis was used to determine the independent contribution of clinical and genetic risk factors to the first occurrence of trigger-specific cardiac events, categorized as arousal, exercise-induced, and nonarousal/nonexercise, from birth through

SUBMITTER: Kim JA 

PROVIDER: S-EPMC3032939 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature