A mathematical framework for protein structure comparison.

ABSTRACT: Comparison of protein structures is important for revealing the evolutionary relationship among proteins, predicting protein functions and predicting protein structures. Many methods have been developed in the past to align two or multiple protein structures. Despite the importance of this problem, rigorous mathematical or statistical frameworks have seldom been pursued for general protein structure comparison. One notable issue in this field is that with many different distances used to measure the similarity between protein structures, none of them are proper distances when protein structures of different sequences are compared. Statistical approaches based on those non-proper distances or similarity scores as random variables are thus not mathematically rigorous. In this work, we develo

SUBMITTER: Liu W 

PROVIDER: S-EPMC3033361 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature