Simple structural differences between coding and noncoding DNA.

ABSTRACT:

Background

The study of large-scale genome structure has revealed patterns suggesting the influence of evolutionary constraints on genome evolution. However, the results of these studies can be difficult to interpret due to the conceptual complexity of the analyses. This makes it difficult to understand how observed statistical patterns relate to the physical distribution of genomic elements. We use a simpler and more intuitive approach to evaluate patterns of genome structure.

Methodology/principal findings

We used randomization tests based on Morisita's Index of aggregation to examine average differences in the distribution of purines and pyrimidines among coding and noncoding regions of 261 chromosomes from 223 microbial genomes representing 21 phylum level groups. Purine

SUBMITTER: Locey KJ 

PROVIDER: S-EPMC3033402 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature