Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans.

ABSTRACT:

Background

Preconditioning environments or therapeutics, to suppress the cellular damage associated with severe oxygen deprivation, is of interest to our understanding of diseases associated with oxygen deprivation. Wildtype C. elegans exposed to anoxia enter into a state of suspended animation in which energy-requiring processes reversibly arrest. C. elegans at all developmental stages survive 24-hours of anoxia exposure however, the ability of adult hermaphrodites to survive three days of anoxia significantly decreases. Mutations in the insulin-like signaling receptor (daf-2) and LIN-12/Notch (glp-1) lead to an enhanced long-term anoxia survival phenotype.

Methodology/principal findings

In this study we show that the combined growth environment of 25°C and a diet of HT115

SUBMITTER: LaRue BL 

PROVIDER: S-EPMC3033420 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature