Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus.

ABSTRACT:

Background

Evidence is beginning to emerge that there may be susceptibility loci for rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) that are common to both diseases.

Objective

To investigate single nucleotide polymorphisms that have been reported to be associated with SLE in a UK cohort of patients with RA and controls.

Methods

3962 patients with RA and 9275 controls were included in the study. Eleven SNPs mapping to confirmed SLE loci were investigated. These mapped to the TNFSF4, BANK1, TNIP1, PTTG1, UHRF1BP1, ATG5, JAZF1, BLK, KIAA1542, ITGAM and UBE2L3 loci. Genotype frequencies were compared between patients with RA and controls using the trend test.

Results

The SNPs mapping to the BLK and UBE2L3 loci showed significant evidence for assoc

SUBMITTER: Orozco G 

PROVIDER: S-EPMC3033530 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature