Magnetic resonance spectroscopy biomarkers in premanifest and early Huntington disease.

ABSTRACT:

Objectives

To evaluate in vivo brain metabolite differences in control subjects, individuals with premanifest Huntington disease (pre-HD), and individuals with early HD using ¹H magnetic resonance spectroscopy (MRS) and to assess their relationship with motor performance.

Methods

Eighty-five participants (30 controls, 25 pre-HD, and 30 early HD) were recruited as part of the TRACK-HD study. Eighty-four were scanned at 3 T with single-voxel spectroscopy in the left putamen. Disease burden score was >220 among pre-HD individuals. Subjects underwent TRACK-HD motor assessment including Unified Huntington's Disease Rating Scale (UHDRS) motor scoring and a novel quantitative motor battery. Statistical analyses included linear regression and one-way analysis of variance.

Results

SUBMITTER: Sturrock A 

PROVIDER: S-EPMC3033605 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature