Single- and double-stranded DNA binding proteins act in concert to conserve a telomeric DNA core sequence.

ABSTRACT:

Background

Telomeres are protective cap structures at the ends of the linear eukaryotic chromosomes, which provide stability to the genome by shielding from degradation and chromosome fusions. The cap consists of telomere-specific proteins binding to the respective single- and double-stranded parts of the telomeric sequence. In addition to the nucleation of the chromatin structure the telomere-binding proteins are involved in the regulation of the telomere length. However, the telomeric sequences are highly diverged among yeast species. During the evolution this high rate of divergency presents a challenge for the sequence recognition of the telomere-binding proteins.

Results

We found that the Saccharomyces castellii protein Rap1, a negative regulator of telomere length, bin

SUBMITTER: Rhodin Edso J 

PROVIDER: S-EPMC3033795 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature