Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases.

ABSTRACT:

Background

Systems biological approach of molecular connectivity map has reached to a great interest to understand the gene functional similarities between the diseases. In this study, we developed a computational framework to build molecular connectivity maps by integrating mutated and differentially expressed genes of neurological and psychiatric diseases to determine its relationship with aging.

Results

The systematic large-scale analyses of 124 human diseases create three classes of molecular connectivity maps. First, molecular interaction of disease protein network generates 3632 proteins with 6172 interactions, which determines the common genes/proteins between diseases. Second, Disease-disease network includes 4845 positively scored disease-disease relationships. The

SUBMITTER: Ahmed SS 

PROVIDER: S-EPMC3033822 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature