Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study.

ABSTRACT: Kawasaki disease (KD) is an acute systemic vasculitis syndrome that primarily affects infants and young children. Its etiology is unknown; however, epidemiological findings suggest that genetic predisposition underlies disease susceptibility. Taiwan has the third-highest incidence of KD in the world, after Japan and Korea. To investigate novel mechanisms that might predispose individuals to KD, we conducted a genome-wide association study (GWAS) in 250 KD patients and 446 controls in a Han Chinese population residing in Taiwan, and further validated our findings in an independent Han Chinese cohort of 208 cases and 366 controls. The most strongly associated single-nucleotide polymorphisms (SNPs) detected in the joint analysis corresponded to three novel loci. Among these KD-associated SNPs

SUBMITTER: Tsai FJ 

PROVIDER: S-EPMC3033903 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature