Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment.

ABSTRACT: Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate.

SUBMITTER: Chen SH 

PROVIDER: S-EPMC303395 | biostudies-literature | 2004 Jan

REPOSITORIES: biostudies-literature