Genetic associations in diabetic nephropathy: a meta-analysis.

ABSTRACT:

Aims/hypothesis

This meta-analysis assessed the pooled effect of each genetic variant reproducibly associated with diabetic nephropathy.

Methods

PubMed, EMBASE and Web of Science were searched for articles assessing the association between genes and diabetic nephropathy. All genetic variants statistically associated with diabetic nephropathy in an initial study, then independently reproduced in at least one additional study, were selected. Subsequently, all studies assessing these variants were included. The association between these variants and diabetic nephropathy (defined as macroalbuminuria/proteinuria or end-stage renal disease [ESRD]) was calculated at the allele level and the main measure of effect was a pooled odds ratio. Pre-specified subgroup analyses were perform

SUBMITTER: Mooyaart AL 

PROVIDER: S-EPMC3034040 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature