Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats.

ABSTRACT:

Objectives

Aldosterone is well recognized as the selective physiological ligand for mineralocorticoid receptor in epithelia. However, in-vitro studies have demonstrated that the affinity of aldosterone and glucocorticoids for mineralocorticoid receptor is similar. We hypothesized that glucocorticoids are involved in the development of renal injury through an mineralocorticoid receptor-dependent mechanism.

Methods and results

Uninephrectomized (UNX) rats were treated with 1% NaCl and divided into three groups: vehicle, bilateral adrenalectomy (ADX) + hydrocortisone (HYDRO; 5 mg/kg/day, s.c.), ADX + HYDRO + eplerenone (0.125% in chow). HYDRO-treated UNX-ADX rats showed increased blood pressure and urinary albumin-to-creatinine ratio with an increase in the expression of the mi

SUBMITTER: Rafiq K 

PROVIDER: S-EPMC3034279 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature