Olfaction in Parkin heterozygotes and compound heterozygotes: the CORE-PD study.

ABSTRACT:

Background

While Parkinson disease (PD) is consistently associated with impaired olfaction, one study reported better olfaction among Parkin mutation carriers than noncarriers. Whether olfaction differs between Parkin mutation heterozygotes and carriers of 2 Parkin mutations (compound heterozygotes) is unknown.

Objective

To assess the relationship between Parkin genotype and olfaction in PD probands and their unaffected relatives.

Methods

We administered the University of Pennsylvania Smell Identification Test (UPSIT) to 44 probands in the Consortium on Risk for Early-Onset Parkinson Disease study with PD onset ≤50 years (10 Parkin mutation heterozygotes, 9 compound heterozygotes, 25 noncarriers) and 80 of their family members (18 heterozygotes, 2 compound heterozygot

SUBMITTER: Alcalay RN 

PROVIDER: S-EPMC3034420 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature