Role of toll-like receptor 4 in intimal foam cell accumulation in apolipoprotein E-deficient mice.

ABSTRACT:

Objective

Atherosclerosis encompasses a conspicuously maladaptive inflammatory response that might involve innate immunity. Here, we compared the role of Toll-like receptor 4 (TLR4) with that of TLR2 in intimal foam cell accumulation and inflammation in apolipoprotein E (ApoE) knockout (KO) mice in vivo and determined potential mechanisms of upstream activation and downstream action.

Methods and results

We measured lipid accumulation and gene expression in the lesion-prone lesser curvature of the aortic arch. TLR4 deficiency reduced intimal lipid by ≈75% in ApoE KO mice, despite unaltered total serum cholesterol and triglyceride levels, whereas TLR2 deficiency reduced it by ≈45%. TLR4 deficiency prevented the increased interleukin-1α (IL-1α) and monocyte chemoattractant prot

SUBMITTER: Higashimori M 

PROVIDER: S-EPMC3034636 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature