Regulation and expression of sexual differentiation factors in embryonic and extragonadal tissues of Atlantic salmon.

ABSTRACT:

Background

The products of cyp19, dax, foxl2, mis, sf1 and sox9 have each been associated with sex-determining processes among vertebrates. We provide evidence for expression of these regulators very early in salmonid development and in tissues outside of the hypothalamic-pituitary-adrenal/gonadal (HPAG) axis. Although the function of these factors in sexual differentiation have been defined, their roles in early development before sexual fate decisions and in tissues beyond the brain or gonad are essentially unknown.

Results

Bacterial artificial chromosomes containing salmon dax1 and dax2, foxl2b and mis were isolated and the regulatory regions that control their expression were characterized. Transposon integrations are implicated in the shaping of the dax and foxl2 loci.

SUBMITTER: von Schalburg KR 

PROVIDER: S-EPMC3034696 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature