Induction and requirement of gene expression in the anterior cingulate cortex and medial prefrontal cortex for the consolidation of inhibitory avoidance memory.

ABSTRACT:

Background

Memory consolidation is a process to stabilize short-term memory, generating long-term memory. A critical biochemical feature of memory consolidation is a requirement for gene expression. Previous studies have shown that fear memories are consolidated through the activation of gene expression in the amygdala and hippocampus, indicating essential roles of these brain regions in memory formation. However, it is still poorly understood whether gene expression in brain regions other than the amygdala/hippocampus is required for the consolidation of fear memory; however, several brain regions are known to play modulatory roles in fear memory formation.

Results

To further understand the mechanisms underlying the formation of fear memory, we first identified brain region

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3035037 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature