Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites.

ABSTRACT:

Background

in many differentiated cells, microtubules are organized into polarized noncentrosomal arrays, yet few mechanisms that control these arrays have been identified. For example, mechanisms that maintain microtubule polarity in the face of constant remodeling by dynamic instability are not known. Drosophila neurons contain uniform-polarity minus-end-out microtubules in dendrites, which are often highly branched. Because undirected microtubule growth through dendrite branch points jeopardizes uniform microtubule polarity, we have used this system to understand how cells can maintain dynamic arrays of polarized microtubules.

Results

we find that growing microtubules navigate dendrite branch points by turning the same way, toward the cell body, 98% of the time and that g

SUBMITTER: Mattie FJ 

PROVIDER: S-EPMC3035180 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature