Antibiotic selectivity for prokaryotic vs. eukaryotic decoding sites.

ABSTRACT: A FRET assembly reports antibiotic affinities to two different RNA targets. A binder was labeled with a fluorophore that acts both as an acceptor for the emissive nucleoside on the bacterial A-site and a donor fluorophore for the terminally-labeled human A-site. Unlabeled drugs were used to dissociate the labeled antibiotic.

SUBMITTER: Xie Y 

PROVIDER: S-EPMC3035430 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature