MiRNA-miRNA synergistic network: construction via co-regulating functional modules and disease miRNA topological features.

ABSTRACT: Synergistic regulations among multiple microRNAs (miRNAs) are important to understand the mechanisms of complex post-transcriptional regulations in humans. Complex diseases are affected by several miRNAs rather than a single miRNA. So, it is a challenge to identify miRNA synergism and thereby further determine miRNA functions at a system-wide level and investigate disease miRNA features in the miRNA-miRNA synergistic network from a new view. Here, we constructed a miRNA-miRNA functional synergistic network (MFSN) via co-regulating functional modules that have three features: common targets of corresponding miRNA pairs, enriched in the same gene ontology category and close proximity in the protein interaction network. Predicted miRNA synergism is validated by significantly high co-expressio

SUBMITTER: Xu J 

PROVIDER: S-EPMC3035454 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature