Evidences for increased expression variation of duplicate genes in budding yeast: from cis- to trans-regulation effects.

ABSTRACT: Duplicate genes tend to have a more variable expression program than singleton genes, which was thought to be an important way for the organism to respond and adapt to fluctuating environment. However, the underlying molecular mechanisms driving such expression variation remain largely unexplored. In this work, we first rigorously confirmed that duplicate genes indeed have higher gene expression variation than singleton genes in several aspects, i.e. responses to environmental perturbation, between-strain divergence, and expression noise. To investigate the underlying mechanism, we further analyzed a previously published expression dataset of yeast segregants produced from genetic crosses. We dissected the observed expression divergence between segregant strains into cis- and trans-variabi

SUBMITTER: Dong D 

PROVIDER: S-EPMC3035465 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature