L-methylfolate Plus SSRI or SNRI from Treatment Initiation Compared to SSRI or SNRI Monotherapy in a Major Depressive Episode.

ABSTRACT:

Objective

Evaluate the efficacy of L-methylfolate in combination with SSRI or SNRI compared to SSRI or SNRI monotherapy in a major depressive episode.

Design

A retrospective analysis of L-methylfolate plus SSRI/SNRI at treatment initiation (n=95) and SSRI/SNRI monotherapy (n=147) from patient charts.

Setting

Outpatient, private psychiatric clinic/practice.

Participants

Adults 18 to 70 with major depressive episode (single or recurrent).

Measurements

Clinical Global Impressions-Severity (CGI-S) and safety/tolerability measures.

Results

Major improvement (CGI-S reduced by ≥2 points) was experienced by 18.5 percent of L-methylfolate plus SSRI/SNRI patients (CGI-S=4-5) compared to 7.04 percent of SSRI/SNRI monotherapy (p=0.01) patients at 60 days. For

SUBMITTER: Ginsberg LD 

PROVIDER: S-EPMC3036555 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature