Identification of novel conserved functional motifs across most Influenza A viral strains.

ABSTRACT:

Background

Influenza A virus poses a continuous threat to global public health. Design of novel universal drugs and vaccine requires a careful analysis of different strains of Influenza A viral genome from diverse hosts and subtypes. We performed a systematic in silico analysis of Influenza A viral segments of all available Influenza A viral strains and subtypes and grouped them based on host, subtype, and years isolated, and through multiple sequence alignments we extrapolated conserved regions, motifs, and accessible regions for functional mapping and annotation.

Results

Across all species and strains 87 highly conserved regions (conservation percentage > = 90%) and 19 functional motifs (conservation percentage = 100%) were found in PB2, PB1, PA, NP, M, and NS segments. Th

SUBMITTER: ElHefnawi M 

PROVIDER: S-EPMC3036627 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature