Genetic incorporation of human metallothionein into the adenovirus protein IX for non-invasive SPECT imaging.

ABSTRACT: As the limits of existing treatments for cancer are recognized, clearly novel therapies must be considered for successful treatment; cancer therapy using adenovirus vectors is a promising strategy. However tracking the biodistribution of adenovirus vectors in vivo is limited to invasive procedures such as biopsies, which are error prone, non-quantitative, and do not give a full representation of the pharmacokinetics involved. Current non-invasive imaging strategies using reporter gene expression have been applied to analyze adenoviral vectors. The major drawback to approaches that tag viruses with reporter genes is that these systems require initial viral infection and subsequent cellular expression of a reporter gene to allow non-invasive imaging. As an alternative to conventional vector

SUBMITTER: Mathis JM 

PROVIDER: S-EPMC3036658 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature