Salmonella enterica serovar Typhimurium lacking hfq gene confers protective immunity against murine typhoid.

ABSTRACT: Salmonella enterica is an important enteric pathogen and its various serovars are involved in causing both systemic and intestinal diseases in humans and domestic animals. The emergence of multidrug-resistant strains of Salmonella leading to increased morbidity and mortality has further complicated its management. Live attenuated vaccines have been proven superior over killed or subunit vaccines due to their ability to induce protective immunity. Of the various strategies used for the generation of live attenuated vaccine strains, focus has gradually shifted towards manipulation of virulence regulator genes. Hfq is a RNA chaperon which mediates the binding of small RNAs to the mRNA and assists in post-transcriptional gene regulation in bacteria. In this study, we evaluated the efficacy of

SUBMITTER: Allam US 

PROVIDER: S-EPMC3036662 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature