Expression and regulation of the Fkbp5 gene in the adult mouse brain.

ABSTRACT:

Background

Chronic stress has been found to be a major risk factor for various human pathologies. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, which is tightly regulated via, among others, the glucocorticoid receptor (GR). The activity of the GR is modulated by a variety of proteins, including the co-chaperone FK506 binding protein 51 (FKBP5). Although FKBP5 has been associated with risk for affective disorders and has been implicated in GR sensitivity, previous studies focused mainly on peripheral blood, while information about basal distribution and induction in the central nervous system are sparse.

Methodology/principal findings

In the present study, we describe the basal expression pattern of Fkbp5 mRNA in the brain of adult male mice and show the ind

SUBMITTER: Scharf SH 

PROVIDER: S-EPMC3036725 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature